LE Cell Test (Lupus Erythematosus Cell Test)

Intro:

• The LE cell test is a hematological test historically used in the diagnosis of Systemic Lupus Erythematosus (SLE).
• LE cells are a specific type of neutrophil or other phagocyte that has engulfed the denatured nuclear material (homogenized chromatin) of another cell, forming a homogeneous, round body known as an LE body or hematoxylin body.
• While modern tests like ANA (antinuclear antibody) and anti-dsDNA antibody assays have largely replaced the LE cell test, it still holds historical importance and basic relevance in educational and diagnostic contexts.